Grapefruit-derived nanovectors deliver miR-18a for treatment of liver metastasis of colon cancer by induction of M1 macrophages.

Teng, Yun; Mu, Jingyao; Hu, Xin; Samykutty, Abhilash; Zhuang, Xiaoying; Deng, Zhongbin; Zhang, Lifeng; Cao, Pengxiao; Yan, Jun; Miller, Donald; Zhang, Huang-Ge

Teng, Yun; Mu, Jingyao; Hu, Xin; Samykutty, Abhilash; Zhuang, Xiaoying; Deng, Zhongbin; Zhang, Lifeng; Cao, Pengxiao; Yan, Jun; Miller, Donald; Zhang, Huang-Ge.

Afiliação

Teng Y; James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Mu J; James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Hu X; Program in Biostatistics, Bioinformatics and Systems Biology, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA.
Samykutty A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Zhuang X; James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Deng Z; James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Zhang L; James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Cao P; James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Yan J; James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Miller D; James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
Zhang HG; James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.

Oncotarget ; 7(18): 25683-97, 2016 May 03.

Article em En | MEDLINE | ID: mdl-27028860

Assuntos

Citrus paradisi; Neoplasias do Colo/patologia; Terapia Genética/métodos; Neoplasias Hepáticas/secundário; Ativação de Macrófagos/efeitos dos fármacos; MicroRNAs/farmacologia; Animais; Neoplasias do Colo/tratamento farmacológico; Neoplasias do Colo/imunologia; Vetores Genéticos; Lipídeos; Neoplasias Hepáticas/tratamento farmacológico; Neoplasias Hepáticas/imunologia; Macrófagos/imunologia; Camundongos; MicroRNAs/imunologia; Nanopartículas; Extratos Vegetais

Palavras-chave

IRF2; M1 Kupffer cells; grapefruit-derived nanovector; liver metastasis of colon cancer; miR-18a

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Terapia Genética / Neoplasias do Colo / Citrus paradisi / MicroRNAs / Neoplasias Hepáticas / Ativação de Macrófagos Limite: Animals Idioma: En Revista: Oncotarget Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

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