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Anal Canal Carcinoma in a Child With Disorders of Sex Development.
Watanabe, Toshihiko; Horikawa, Reiko; Masaki, Hidekazu; Yoshioka, Takako; Matsumoto, Kimikazu; Kanamori, Yutaka.
Afiliação
  • Watanabe T; Division of Surgery, Department of Surgical Specialties, National Center for Child Health and Development, Tokyo, Japan.
  • Horikawa R; Division of Endocrinology and Metabolism, Department of Medical Specialties, National Center for Child Health and Development, Tokyo, Japan.
  • Masaki H; Department of Radiology, National Center for Child Health and Development, Tokyo, Japan.
  • Yoshioka T; Department of Pathology, National Center for Child Health and Development, Tokyo, Japan.
  • Matsumoto K; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
  • Kanamori Y; Division of Surgery, Department of Surgical Specialties, National Center for Child Health and Development, Tokyo, Japan.
Pediatr Blood Cancer ; 63(7): 1293-5, 2016 07.
Article em En | MEDLINE | ID: mdl-27037640
Squamous cell carcinoma of the anal canal in children is rare. To date, the etiology and outcome of this condition have been not fully understood. Here, we report an 11-year-old child with anal canal cancer who had concomitant disorders of sex development. Radiotherapy followed by salvage surgery achieved disease-free survival of 3 years. Since overexpression of cell cycle regulatory protein p16 was immunohistochemically evident in tumor tissue, human papillomavirus infection was considered as a causative factor in the carcinogenesis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Ânus / Transtornos do Desenvolvimento Sexual / Carcinoma de Células Escamosas Limite: Child / Humans / Male Idioma: En Revista: Pediatr Blood Cancer Assunto da revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Ânus / Transtornos do Desenvolvimento Sexual / Carcinoma de Células Escamosas Limite: Child / Humans / Male Idioma: En Revista: Pediatr Blood Cancer Assunto da revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Japão