Cutaneous, Purpuric Painful Nodules Upon Addition of Ibrutinib to RCVP Therapy in a CLL Patient: A Distinctive Reaction Pattern Reflecting Iatrogenic Th2 to Th1 Milieu Reversal.
Am J Dermatopathol
; 38(7): 492-8, 2016 Jul.
Article
em En
| MEDLINE
| ID: mdl-27043332
ABSTRACT
A 70-year-old white man with stage C chronic lymphocytic leukemia who was being successfully treated with ibrutinib and rituximab developed bilateral, purpuric, painful cutaneous nodules. Biopsies of these nodules did not reveal the usual Th2 milieu of chronic lymphocytic leukemia but instead exhibited a Th1-rich lymphocytic infiltrate with resultant neutrophil and granulomatous inflammation. The eruption resolved with drug cessation emphasizing the potential importance of this drug in treating conditions associated with Th2 dysregulation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
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Pirimidinas
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Pele
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Leucemia Linfocítica Crônica de Células B
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Protocolos de Quimioterapia Combinada Antineoplásica
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Toxidermias
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Células Th2
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Células Th1
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Inibidores de Proteínas Quinases
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Rituximab
Limite:
Aged
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Humans
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Male
Idioma:
En
Revista:
Am J Dermatopathol
Ano de publicação:
2016
Tipo de documento:
Article