The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis.

Aprelikova, Olga; Chen, Kenny; El Touny, Lara H; Brignatz-Guittard, Constance; Han, Justin; Qiu, Tinghu; Yang, Howard H; Lee, Maxwell P; Zhu, Min; Green, Jeffrey E

Aprelikova, Olga; Chen, Kenny; El Touny, Lara H; Brignatz-Guittard, Constance; Han, Justin; Qiu, Tinghu; Yang, Howard H; Lee, Maxwell P; Zhu, Min; Green, Jeffrey E.

Afiliação

Aprelikova O; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Building 37, Room 4054, 37 Convent Dr., Bethesda, MD 20892 USA.
Chen K; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Building 37, Room 4054, 37 Convent Dr., Bethesda, MD 20892 USA.
El Touny LH; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Building 37, Room 4054, 37 Convent Dr., Bethesda, MD 20892 USA.
Brignatz-Guittard C; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Building 37, Room 4054, 37 Convent Dr., Bethesda, MD 20892 USA.
Han J; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Building 37, Room 4054, 37 Convent Dr., Bethesda, MD 20892 USA.
Qiu T; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Building 37, Room 4054, 37 Convent Dr., Bethesda, MD 20892 USA.
Yang HH; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Building 37, Room 4054, 37 Convent Dr., Bethesda, MD 20892 USA.
Lee MP; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Building 37, Room 4054, 37 Convent Dr., Bethesda, MD 20892 USA.
Zhu M; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Building 37, Room 4054, 37 Convent Dr., Bethesda, MD 20892 USA.
Green JE; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Building 37, Room 4054, 37 Convent Dr., Bethesda, MD 20892 USA.

Clin Epigenetics ; 8: 38, 2016.

Article em En | MEDLINE | ID: mdl-27081402

Assuntos

Neoplasias da Mama/patologia; Transformação Celular Neoplásica/genética; Epigênese Genética; Histona Desmetilases com o Domínio Jumonji/genética; Neoplasias Mamárias Experimentais/patologia; Proteínas Proto-Oncogênicas c-myc/genética; Animais; Apoptose; Neoplasias da Mama/genética; Neoplasias da Mama/metabolismo; Linhagem Celular Tumoral; Transformação Celular Neoplásica/metabolismo; Hibridização Genômica Comparativa; Feminino; Regulação Neoplásica da Expressão Gênica; Humanos; Histona Desmetilases com o Domínio Jumonji/metabolismo; Neoplasias Mamárias Experimentais/genética; Neoplasias Mamárias Experimentais/metabolismo; Camundongos; Metástase Neoplásica; Prognóstico; Proteínas Proto-Oncogênicas c-myc/metabolismo; Transdução de Sinais

Palavras-chave

Copy number variants; Epigenetics; JMJD6; Mammary cancer; Myc; Tumor progression

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Transformação Celular Neoplásica / Proteínas Proto-Oncogênicas c-myc / Epigênese Genética / Histona Desmetilases com o Domínio Jumonji / Neoplasias Mamárias Experimentais Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Clin Epigenetics Ano de publicação: 2016 Tipo de documento: Article

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