Qualification of a Quantitative Method for Monitoring Aspartate Isomerization of a Monoclonal Antibody by Focused Peptide Mapping.

Cao, Mingyan; Mo, Wenjun David; Shannon, Anthony; Wei, Ziping; Washabaugh, Michael; Cash, Patricia

Cao, Mingyan; Mo, Wenjun David; Shannon, Anthony; Wei, Ziping; Washabaugh, Michael; Cash, Patricia.

Afiliação

Cao M; Analytical Biotechnology Department, MedImmune Inc, Gaithersburg, MD.
Mo WD; Analytical Biotechnology Department, MedImmune Inc, Gaithersburg, MD.
Shannon A; Analytical Biotechnology Department, MedImmune Inc, Gaithersburg, MD.
Wei Z; Analytical Biotechnology Department, MedImmune Inc, Gaithersburg, MD.
Washabaugh M; Analytical Biotechnology Department, MedImmune Inc, Gaithersburg, MD michael.washabaugh@theraproteins.com Patriciacash8@gmail.com.
Cash P; Analytical Biotechnology Department, MedImmune Inc, Gaithersburg, MD michael.washabaugh@theraproteins.com Patriciacash8@gmail.com.

PDA J Pharm Sci Technol ; 70(6): 490-507, 2016.

Article em En | MEDLINE | ID: mdl-27091886

Assuntos

Mapeamento de Peptídeos; Sequência de Aminoácidos; Anticorpos Monoclonais; Ácido Aspártico; Cromatografia Líquida de Alta Pressão; Regiões Determinantes de Complementaridade; Isomerismo; Proteínas Recombinantes; Espectrometria de Massas em Tandem

Palavras-chave

Aspartic acid isomerization; Complementarity-determining regions (CDRs); Focused peptide mapping; Method qualification; Monoclonal antibody (mAb)

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Base de dados: MEDLINE Assunto principal: Mapeamento de Peptídeos Idioma: En Revista: PDA J Pharm Sci Technol Assunto da revista: FARMACIA / FARMACOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Moldávia

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