A New, Dynamic Era for Somatic Cell Nuclear Transfer?
Trends Biotechnol
; 34(10): 791-797, 2016 10.
Article
em En
| MEDLINE
| ID: mdl-27118511
ABSTRACT
Cloning animals by somatic cell nuclear transfer (SCNT) has remained an uncontrollable process for many years. High rates of embryonic losses, stillbirths, and postnatal mortality have been typical outcomes. These developmental problems arise from abnormal genomic reprogramming the capacity of the oocyte to reset the differentiated memory of a somatic cell. However, effective reprogramming strategies are now available. These target the whole genome or single domains such as the Xist gene, and their effectiveness has been validated with the ability of experimental animals to develop to term. Thus, SCNT has become a controllable process that can be used to 'rescue' endangered species, and for biomedical research such as therapeutic cloning and the isolation of induced pluripotent stem cells (iPSCs).
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Clonagem de Organismos
/
Técnicas de Transferência Nuclear
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biotechnol
Ano de publicação:
2016
Tipo de documento:
Article