Smad2/3 Proteins Are Required for Immobilization-induced Skeletal Muscle Atrophy.

Tando, Toshimi; Hirayama, Akiyoshi; Furukawa, Mitsuru; Sato, Yuiko; Kobayashi, Tami; Funayama, Atsushi; Kanaji, Arihiko; Hao, Wu; Watanabe, Ryuichi; Morita, Mayu; Oike, Takatsugu; Miyamoto, Kana; Soga, Tomoyoshi; Nomura, Masatoshi; Yoshimura, Akihiko; Tomita, Masaru; Matsumoto, Morio; Nakamura, Masaya; Toyama, Yoshiaki; Miyamoto, Takeshi

Tando, Toshimi; Hirayama, Akiyoshi; Furukawa, Mitsuru; Sato, Yuiko; Kobayashi, Tami; Funayama, Atsushi; Kanaji, Arihiko; Hao, Wu; Watanabe, Ryuichi; Morita, Mayu; Oike, Takatsugu; Miyamoto, Kana; Soga, Tomoyoshi; Nomura, Masatoshi; Yoshimura, Akihiko; Tomita, Masaru; Matsumoto, Morio; Nakamura, Masaya; Toyama, Yoshiaki; Miyamoto, Takeshi.

Afiliação

Tando T; From the Departments of Orthopedic Surgery.
Hirayama A; the Institute for Advanced Biosciences, Keio University, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata 997-0052, and.
Furukawa M; From the Departments of Orthopedic Surgery.
Sato Y; From the Departments of Orthopedic Surgery, Musculoskeletal Reconstruction and Regeneration Surgery.
Kobayashi T; From the Departments of Orthopedic Surgery, Musculoskeletal Reconstruction and Regeneration Surgery.
Funayama A; From the Departments of Orthopedic Surgery.
Kanaji A; From the Departments of Orthopedic Surgery.
Hao W; From the Departments of Orthopedic Surgery.
Watanabe R; From the Departments of Orthopedic Surgery.
Morita M; Dentistry and Oral Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582.
Oike T; From the Departments of Orthopedic Surgery.
Miyamoto K; From the Departments of Orthopedic Surgery.
Soga T; the Institute for Advanced Biosciences, Keio University, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata 997-0052, and.
Nomura M; the Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Maidashi 3-1-1, Higashi Ward, Fukuoka 812-8582, Japan.
Yoshimura A; Immunology, and.
Tomita M; the Institute for Advanced Biosciences, Keio University, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata 997-0052, and.
Matsumoto M; From the Departments of Orthopedic Surgery.
Nakamura M; From the Departments of Orthopedic Surgery.
Toyama Y; From the Departments of Orthopedic Surgery.
Miyamoto T; From the Departments of Orthopedic Surgery, miyamoto@z5.keio.jp.

J Biol Chem ; 291(23): 12184-94, 2016 Jun 03.

Article em En | MEDLINE | ID: mdl-27129272

Assuntos

Músculo Esquelético/metabolismo; Atrofia Muscular/metabolismo; Proteína Smad2/metabolismo; Proteína Smad3/metabolismo; Aminoácidos de Cadeia Ramificada/metabolismo; Animais; Western Blotting; Linhagem Celular; Glucose/metabolismo; Fator de Crescimento Insulin-Like I/metabolismo; Fator de Crescimento Insulin-Like I/farmacologia; Camundongos Knockout; Camundongos Transgênicos; Denervação Muscular; Fibras Musculares Esqueléticas/citologia; Fibras Musculares Esqueléticas/efeitos dos fármacos; Fibras Musculares Esqueléticas/metabolismo; Proteínas Musculares/genética; Proteínas Musculares/metabolismo; Músculo Esquelético/inervação; Músculo Esquelético/patologia; Atrofia Muscular/etiologia; Miostatina/genética; Miostatina/metabolismo; Receptor IGF Tipo 1/genética; Receptor IGF Tipo 1/metabolismo; Restrição Física/efeitos adversos; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Proteínas Ligases SKP Culina F-Box/genética; Proteínas Ligases SKP Culina F-Box/metabolismo; Proteína Smad2/genética; Proteína Smad3/genética; Proteínas com Motivo Tripartido/genética; Proteínas com Motivo Tripartido/metabolismo; Ubiquitina-Proteína Ligases/genética; Ubiquitina-Proteína Ligases/metabolismo

Palavras-chave

SMAD transcription factor; metabolism; muscle; muscle atrophy; myostatin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Atrofia Muscular / Músculo Esquelético / Proteína Smad2 / Proteína Smad3 Tipo de estudo: Etiology_studies / Prognostic_studies Idioma: En Revista: J Biol Chem Ano de publicação: 2016 Tipo de documento: Article

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