Physics-driven impeller designs for a novel intravascular blood pump for patients with congenital heart disease.
Med Eng Phys
; 38(7): 622-632, 2016 07.
Article
em En
| MEDLINE
| ID: mdl-27129783
Mechanical circulatory support offers an alternative therapeutic treatment for patients with dysfunctional single ventricle physiology. An intravascular axial flow pump is being developed as a cavopulmonary assist device for these patients. This study details the development of a new rotating impeller geometry. We examined the performance of 8 impeller geometries with blade stagger or twist angles varying from 100° to 800° using computational methods. A refined range of blade twist angles between 300° and 400° was then identified, and 4 additional geometries were evaluated. Generally, the impeller designs produced 4-26mmHg for flow rates of 1-4L/min for 6000-8000 RPM. A data regression analysis was completed and found the impeller with 400° of blade twist to be the superior performer. A hydraulic test was conducted on a prototype of the 400° impeller, which generated measurable pressure rises of 7-28mmHg for flow rates of 1-4L/min at 6000-8000 RPM. The findings of the numerical model and experiment were in reasonable agreement within approximately 20%. These results support the continued development of an axial-flow, mechanical cavopulmonary assist device as a new clinical therapeutic option for Fontan patients.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Desenho de Prótese
/
Coração Auxiliar
/
Fenômenos Mecânicos
/
Cardiopatias Congênitas
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Med Eng Phys
Assunto da revista:
BIOFISICA
/
ENGENHARIA BIOMEDICA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos