The association of HTR3A mRNA expression and craving in Han Chinese alcohol-dependent patients: a preliminary study.
Am J Drug Alcohol Abuse
; 42(3): 316-24, 2016 05.
Article
em En
| MEDLINE
| ID: mdl-27144979
ABSTRACT
BACKGROUND:
5-Hydroxytryptamine (5-HT) 3 receptor plays a crucial role in craving of alcohol dependence. Recent evidence shows that chronic alcohol exposure causes changes in gene expression and induces behavioral changes. However, the relationship between gene expression of 5-HT3 receptor and craving in alcohol-dependent patients is not fully understood.OBJECTIVES:
The aim of this preliminary study was to investigate the relationship between gene expression of the 5-HT3 receptor and craving in alcohol-dependent patients and the epigenetic mechanism.METHODS:
We recruited 50 male Han Chinese alcohol-dependent patients and 46 male Han Chinese healthy controls. We investigated the changes of HTR3A mRNA, which encodes the 5-HT3 receptor A subunit, and H3K9 acetylation in HTR3A promoter region. Obsessive Compulsive Drinking Scale (OCDS) was used to assess the craving of alcohol-dependent patients relative to controls.RESULTS:
HTR3A mRNA expression levels and acetylation levels of H3K9 in the HTR3A promoter region were significantly higher in the alcohol-dependent patients. HTR3A mRNA expression levels were positively correlated with OCDS scores. Moreover, HTR3A mRNA expression levels were positively correlated with acetylation levels of H3K9 in HTR3A promoter region.CONCLUSION:
The current findings suggest that HTR3A mRNA expression levels were positively correlated with craving in Han Chinese alcohol-dependent patients. The regulation of H3K9 histone acetylation in HTR3A promoter region may offer a target for the treatment of alcohol dependence.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores 5-HT3 de Serotonina
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Povo Asiático
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Alcoolismo
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Fissura
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Am J Drug Alcohol Abuse
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
China