In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.

Bossi, Daniela; Cicalese, Angelo; Dellino, Gaetano I; Luzi, Lucilla; Riva, Laura; D'Alesio, Carolina; Diaferia, Giuseppe R; Carugo, Alessandro; Cavallaro, Elena; Piccioni, Rossana; Barberis, Massimo; Mazzarol, Giovanni; Testori, Alessandro; Punzi, Simona; Pallavicini, Isabella; Tosti, Giulio; Giacó, Luciano; Melloni, Giorgio; Heffernan, Timothy P; Natoli, Gioacchino; Draetta, Giulio F; Minucci, Saverio; Pelicci, PierGiuseppe; Lanfrancone, Luisa

Bossi, Daniela; Cicalese, Angelo; Dellino, Gaetano I; Luzi, Lucilla; Riva, Laura; D'Alesio, Carolina; Diaferia, Giuseppe R; Carugo, Alessandro; Cavallaro, Elena; Piccioni, Rossana; Barberis, Massimo; Mazzarol, Giovanni; Testori, Alessandro; Punzi, Simona; Pallavicini, Isabella; Tosti, Giulio; Giacó, Luciano; Melloni, Giorgio; Heffernan, Timothy P; Natoli, Gioacchino; Draetta, Giulio F; Minucci, Saverio; Pelicci, PierGiuseppe; Lanfrancone, Luisa.

Afiliação

Bossi D; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
Cicalese A; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
Dellino GI; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy. Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy.
Luzi L; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
Riva L; Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, Milan, Italy.
D'Alesio C; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
Diaferia GR; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
Carugo A; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Cavallaro E; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
Piccioni R; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
Barberis M; Division of Pathology, European Institute of Oncology, Milan, Italy.
Mazzarol G; Division of Pathology, European Institute of Oncology, Milan, Italy.
Testori A; Division of Dermatoncology, European Institute of Oncology, Milan, Italy.
Punzi S; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
Pallavicini I; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
Tosti G; Division of Dermatoncology, European Institute of Oncology, Milan, Italy.
Giacó L; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
Melloni G; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
Heffernan TP; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Natoli G; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
Draetta GF; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
Minucci S; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy. Department of Biosciences, University of Milan, Milan, Italy.
Pelicci P; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy. Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy.
Lanfrancone L; Department of Experimental Oncology, European Institute of Oncology, Milan, Italy. luisa.lanfrancone@ieo.eu.

Cancer Discov ; 6(6): 650-63, 2016 06.

Article em En | MEDLINE | ID: mdl-27179036

Assuntos

Transformação Celular Neoplásica/genética; Estudos de Associação Genética; Testes Genéticos; Neoplasias/diagnóstico; Neoplasias/genética; Fenótipo; Animais; Linhagem Celular Tumoral; Imunoprecipitação da Cromatina; Biologia Computacional/métodos; Proteínas de Ligação a DNA/metabolismo; Modelos Animais de Doenças; Elementos Facilitadores Genéticos; Epigênese Genética; Epigenômica/métodos; GTP Fosfo-Hidrolases/genética; GTP Fosfo-Hidrolases/metabolismo; Perfilação da Expressão Gênica; Regulação Neoplásica da Expressão Gênica; Predisposição Genética para Doença; Xenoenxertos; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Masculino; Proteínas de Membrana/genética; Proteínas de Membrana/metabolismo; Camundongos; Metástase Neoplásica; Proteínas de Neoplasias/metabolismo; Ligação Proteica; RNA Interferente Pequeno/genética; Reprodutibilidade dos Testes

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenótipo / Transformação Celular Neoplásica / Testes Genéticos / Estudos de Associação Genética / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Cancer Discov Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Itália

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