[Human growth hormone and Turner syndrome]. / Hormona de crecimiento y síndrome de Turner.
An Pediatr (Barc)
; 86(2): 81-86, 2017 Feb.
Article
em Es
| MEDLINE
| ID: mdl-27179405
ABSTRACT
OBJECTIVE:
The evaluation of clinical and analytical parameters as predictors of the final growth response in Turner syndrome patients treated with growth hormone. MATERIAL ANDMETHODS:
A retrospective study was performed on 25 girls with Turner syndrome (17 treated with growth hormone), followed-up until adult height. Auxological, analytical, genetic and pharmacological parameters were collected. A descriptive and analytical study was conducted to evaluate short (12 months) and long term response to treatment with growth hormone.RESULTS:
A favourable treatment response was shown during the first year of treatment in terms of height velocity gain in 66.6% of cases (height-gain velocity >3cm/year). A favourable long-term treatment response was also observed in terms of adult height, which increased by 42.82±21.23cm (1.25±0.76 SDS), with an adult height gain of 9.59±5.39cm (1.68±1.51 SDS).CONCLUSIONS:
Predictors of good response to growth hormone treatment are A) initial growth hormone dose, B) time on growth hormone treatment until starting oestrogen therapy, C) increased IGF1 and IGFBP-3 levels in the first year of treatment, and D) height gain velocity in the first year of treatment.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Turner
/
Hormônio do Crescimento Humano
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
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Child, preschool
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Female
/
Humans
/
Infant
Idioma:
Es
Revista:
An Pediatr (Barc)
Assunto da revista:
PEDIATRIA
Ano de publicação:
2017
Tipo de documento:
Article