In vitro characterization of belinostat glucuronidation: demonstration of both UGT1A1 and UGT2B7 as the main contributing isozymes.

Dong, Dong; Zhang, Tianpeng; Lu, Danyi; Liu, Jie; Wu, Baojian

Dong, Dong; Zhang, Tianpeng; Lu, Danyi; Liu, Jie; Wu, Baojian.

Afiliação

Dong D; a Ocular Surface Research Center and Institute of Ophthalmology, Jinan University School of Medicine , Guangzhou , China.
Zhang T; b Research Center for Biopharmaceutics and Pharmacokinetics, College of Pharmacy, Jinan University , Guangzhou , China , and.
Lu D; b Research Center for Biopharmaceutics and Pharmacokinetics, College of Pharmacy, Jinan University , Guangzhou , China , and.
Liu J; c Department of Pharmacy , The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou , China.
Wu B; b Research Center for Biopharmaceutics and Pharmacokinetics, College of Pharmacy, Jinan University , Guangzhou , China , and.

Xenobiotica ; 47(4): 277-283, 2017 Apr.

Article em En | MEDLINE | ID: mdl-27180825

Assuntos

Glucuronosiltransferase/metabolismo; Inibidores de Histona Desacetilases/metabolismo; Ácidos Hidroxâmicos/metabolismo; Sulfonamidas/metabolismo; Glucuronídeos

Palavras-chave

Belinostat; UGT; UPLC-QTOF/MS; glucuronidation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sulfonamidas / Glucuronosiltransferase / Inibidores de Histona Desacetilases / Ácidos Hidroxâmicos Idioma: En Revista: Xenobiotica Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

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