GENOME-WIDE MAPPING OF COPY NUMBER VARIATIONS IN COMMERCIAL HYBRID PIGS USING A HIGH-DENSITY SNP GENOTYPING ARRAY.
Genetika
; 52(1): 97-105, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-27183798
ABSTRACT
Copy number variations (CNVs) are important forms of structural variation in human and animals and can be considered as a major genetic component of phenotypic diversity. Here we used the Illumina PorcineSNP60 BeadChip V2 and a DLY [Duroc x (Large White x Landrace)] commercial hybrid population to identify 272 CNVs belonging to 165 CNV regions (CNVRs), of which 66 are new. As CNVRs are specific to origin of population, our DLY-specific data is an important complementary to the existing CNV map in the pig genome. Eight CNVRs were selected. for validation by quantitative real-time PCR (qRT-PCR) and the accurate rate was high (87.25%). Gene function analysis suggested that a common CNVR may play an important role in multiple traits, including growth rate and carcass quality.
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Base de dados:
MEDLINE
Assunto principal:
Cruzamento
/
Mapeamento Cromossômico
/
Sus scrofa
/
Variações do Número de Cópias de DNA
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Genetika
Ano de publicação:
2016
Tipo de documento:
Article