Population-Level Representation of a Temporal Sequence Underlying Song Production in the Zebra Finch.
Neuron
; 90(4): 866-76, 2016 05 18.
Article
em En
| MEDLINE
| ID: mdl-27196976
ABSTRACT
The zebra finch brain features a set of clearly defined and hierarchically arranged motor nuclei that are selectively responsible for producing singing behavior. One of these regions, a critical forebrain structure called HVC, contains premotor neurons that are active at precise time points during song production. However, the neural representation of this behavior at a population level remains elusive. We used two-photon microscopy to monitor ensemble activity during singing, integrating across multiple trials by adopting a Bayesian inference approach to more precisely estimate burst timing. Additionally, we examined spiking and motor-related synaptic inputs using intracellular recordings during singing. With both experimental approaches, we find that premotor events do not occur preferentially at the onsets or offsets of song syllables or at specific subsyllabic motor landmarks. These results strongly support the notion that HVC projection neurons collectively exhibit a temporal sequence during singing that is uncoupled from ongoing movements.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vocalização Animal
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Comportamento Animal
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Potenciais de Ação
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Prosencéfalo
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Tentilhões
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Neuron
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos