The suppressor of cytokine signaling SOCS1 promotes apoptosis of intestinal epithelial cells via p53 signaling in Crohn's disease.

Cui, Xiaopeng; Shan, Xiaohang; Qian, Ji; Ji, Qianqian; Wang, Liang; Wang, Xiaotong; Li, Manhua; Ding, Haifang; Liu, Qingqing; Chen, Lingling; Zhang, Dongmei; Ni, Runzhou

Cui, Xiaopeng; Shan, Xiaohang; Qian, Ji; Ji, Qianqian; Wang, Liang; Wang, Xiaotong; Li, Manhua; Ding, Haifang; Liu, Qingqing; Chen, Lingling; Zhang, Dongmei; Ni, Runzhou.

Afiliação

Cui X; Department of General Surgery, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu Province, People's Republic of China.
Shan X; Department of Gastroenterology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu Province, People's Republic of China; Department of Pathogen Biology, Medical College, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, 19 Q
Qian J; Department of Gastroenterology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu Province, People's Republic of China.
Ji Q; Department of Gastroenterology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu Province, People's Republic of China.
Wang L; Department of Gastroenterology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu Province, People's Republic of China.
Wang X; Department of Gastroenterology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu Province, People's Republic of China; Department of Pathogen Biology, Medical College, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, 19 Q
Li M; Department of Gastroenterology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu Province, People's Republic of China.
Ding H; Department of Gastroenterology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu Province, People's Republic of China.
Liu Q; Department of Gastroenterology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu Province, People's Republic of China.
Chen L; Department of Gastroenterology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu Province, People's Republic of China.
Zhang D; Department of Pathogen Biology, Medical College, Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, 19 Qixiu Road, Nantong 226001, Jiangsu Province, People's Republic of China.
Ni R; Department of Gastroenterology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu Province, People's Republic of China.

Exp Mol Pathol ; 101(1): 1-11, 2016 08.

Article em En | MEDLINE | ID: mdl-27236107

Assuntos

Apoptose; Doença de Crohn/patologia; Células Epiteliais/patologia; Intestinos/patologia; Transdução de Sinais; Proteína 1 Supressora da Sinalização de Citocina/metabolismo; Proteína Supressora de Tumor p53/metabolismo; Animais; Apoptose/efeitos dos fármacos; Colite; Doença de Crohn/metabolismo; Células Epiteliais/efeitos dos fármacos; Células Epiteliais/metabolismo; Feminino; Técnicas de Silenciamento de Genes; Células HT29; Humanos; Interferon gama/farmacologia; Camundongos Endogâmicos BALB C; Transdução de Sinais/efeitos dos fármacos; Ácido Trinitrobenzenossulfônico

Palavras-chave

Apoptosis; Crohn's disease; Intestinal epithelial cells; SOCS1; p53

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Doença de Crohn / Proteína Supressora de Tumor p53 / Apoptose / Células Epiteliais / Proteína 1 Supressora da Sinalização de Citocina / Intestinos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Exp Mol Pathol Ano de publicação: 2016 Tipo de documento: Article

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