Age-dependent modulation of tissue-specific repair activity for 3-methyladenine and O6-methylguanine in DNA in inbred mice.
Mech Ageing Dev
; 48(1): 43-52, 1989 Apr.
Article
em En
| MEDLINE
| ID: mdl-2725074
ABSTRACT
3-Methyladenine-DNA N-glycosylase (MAG) and O6-methylguanine-DNA methyltransferase (MGMT) activities were assayed in liver, lungs, brain and ovaries of female mice of two inbred stocks, C3Hf and C57BL/E, as a function of age. In addition to differences in the enzyme levels between the two stocks for each organ, the suckling animals (9-day-old) have consistently lower levels of both MAG and MGMT than young adults (7- or 8-week-old). While the MGMT levels in adults did not decrease with age, the MAG levels in 15- to 17-month-old animals were, in general, significantly lower than those in young adults. These results raise the possibility that the older animals are at a higher risk than young adults following exposure to alkylating mutagens.
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Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
DNA Glicosilases
/
Reparo do DNA
/
Metiltransferases
/
N-Glicosil Hidrolases
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Mech Ageing Dev
Ano de publicação:
1989
Tipo de documento:
Article