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Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.
Jia, Yong; Yun, Cai-Hong; Park, Eunyoung; Ercan, Dalia; Manuia, Mari; Juarez, Jose; Xu, Chunxiao; Rhee, Kevin; Chen, Ting; Zhang, Haikuo; Palakurthi, Sangeetha; Jang, Jaebong; Lelais, Gerald; DiDonato, Michael; Bursulaya, Badry; Michellys, Pierre-Yves; Epple, Robert; Marsilje, Thomas H; McNeill, Matthew; Lu, Wenshuo; Harris, Jennifer; Bender, Steven; Wong, Kwok-Kin; Jänne, Pasi A; Eck, Michael J.
Afiliação
  • Jia Y; Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.
  • Yun CH; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
  • Park E; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Ercan D; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
  • Manuia M; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Juarez J; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
  • Xu C; Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.
  • Rhee K; Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.
  • Chen T; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
  • Zhang H; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
  • Palakurthi S; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
  • Jang J; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
  • Lelais G; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
  • DiDonato M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
  • Bursulaya B; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Michellys PY; Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.
  • Epple R; Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.
  • Marsilje TH; Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.
  • McNeill M; Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.
  • Lu W; Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.
  • Harris J; Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.
  • Bender S; Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.
  • Wong KK; Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.
  • Jänne PA; Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.
  • Eck MJ; Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.
Nature ; 534(7605): 129-32, 2016 06 02.
Article em En | MEDLINE | ID: mdl-27251290
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiazóis / Resistencia a Medicamentos Antineoplásicos / Benzenoacetamidas / Inibidores de Proteínas Quinases / Proteínas Mutantes / Receptores ErbB / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nature Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiazóis / Resistencia a Medicamentos Antineoplásicos / Benzenoacetamidas / Inibidores de Proteínas Quinases / Proteínas Mutantes / Receptores ErbB / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nature Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos