Revealing stiffening and brittling of chronic myelogenous leukemia hematopoietic primary cells through their temporal response to shear stress.
Phys Biol
; 13(3): 03LT01, 2016 06 02.
Article
em En
| MEDLINE
| ID: mdl-27254599
ABSTRACT
Cancer cell transformation is often accompanied by a modification of their viscoelastic properties. When capturing the stress-to-strain response of primary chronic myelogenous leukemia (CML) cells, from two data sets of CD34+ hematopoietic cells isolated from healthy and leukemic bone marrows, we show that the mean shear relaxation modulus increases upon cancer transformation. This stiffening of the cells comes along with local rupture events, detected as reinforced sharp local maxima of this modulus, suggesting that these cancer cells respond to a local mechanical stress by a cascade of local brittle failure events.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estresse Mecânico
/
Leucemia Mielogênica Crônica BCR-ABL Positiva
/
Resistência ao Cisalhamento
Limite:
Humans
Idioma:
En
Revista:
Phys Biol
Assunto da revista:
BIOLOGIA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
França