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Effects of Radiation Therapy on Immunological and Virological Status in HIV-Infected Cancer Patients in Thailand: A Multicenter Prospective Study.
J Med Assoc Thai ; 99 Suppl 2: S9-16, 2016 Feb.
Article em En | MEDLINE | ID: mdl-27266211
ABSTRACT

BACKGROUND:

Radiation therapy (RT) is the core part of cancer multidisciplinary management which causes myelosuppression. The current standard or RT among HIV-positive cancer patients who are immuno-compromised does not differ from that of HIV-negative ones.

OBJECTIVE:

To determine the effects of radiation therapy on immunological and virological status among HIV-infected cancer patients. MATERIAL AND

METHOD:

A prospective observational study was conducted of HIV-infected cancer patients who received definitive RT in seven hospitals in Thailand. Blood samples were taken to determine immune status using CD4%, and virological status was identified using plasma HIV-RNA viral load (HIV-VL) assay at baseline before RT at the last week of RT completion; and at the 6-month follow-up visit. Additional CD4% test was performed at the 3-month follow-up visit.

RESULTS:

Ninety HIV-infected cancer patients from seven hospitals in Thailand were included in the analysis. The median age was 40 years old (range 19-61). Seventy-six patients (84.4%) were female and 65 (72.2%) were cases of invasive cervical cancers. Eighty-seven percent of patients had been receiving antiretroviral treatment (ART) before RT The mean CD4% at baseline, RT completion, 3-month and 6-month follow-up visits, were 18.7%, 20.1%, 16.8% and 17.1%, respectively. The proportion of CD4% reduction in the non-ART group was higher than that of the ART group throughout the period, particularly at the 3-month follow-up visit (100% vs. 29.7%, p = 0.0004). Six cases had a HIV-VL increase of more than 10 times (1-log10) at completion of RT 3 of these were non-ART and 3 were ART-uncontrolled viral suppression.

CONCLUSION:

RT had a suppressive effect on immunological status in HIV-infected cancer patients, particularly in the subacute period among those who were not on ART HIV-disease progression was observed during radiation treatment in HIV-infected cancer patients without ART and those with ART-uncontrolled viral suppression.
Assuntos
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Base de dados: MEDLINE Assunto principal: Infecções por HIV / Neoplasias Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: J Med Assoc Thai Ano de publicação: 2016 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Infecções por HIV / Neoplasias Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: J Med Assoc Thai Ano de publicação: 2016 Tipo de documento: Article