How do the macrocyclic lactones kill filarial nematode larvae?
Invert Neurosci
; 16(3): 7, 2016 09.
Article
em En
| MEDLINE
| ID: mdl-27279086
ABSTRACT
The macrocyclic lactones (MLs) are one of the few classes of drug used in the control of the human filarial infections, onchocerciasis and lymphatic filariasis, and the only one used to prevent heartworm disease in dogs and cats. Despite their importance in preventing filarial diseases, the way in which the MLs work against these parasites is unclear. In vitro measurements of nematode motility have revealed a large discrepancy between the maximum plasma concentrations achieved after drug administration and the amounts required to paralyze worms. Recent evidence has shed new light on the likely functions of the ML target, glutamate-gated chloride channels, in filarial nematodes and supports the hypothesis that the rapid clearance of microfilariae that follows treatment involves the host immune system.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Filariose
/
Filaricidas
/
Larva
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Invert Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos