Endoplasmic Reticulum-Plasma Membrane Associations:Structures and Functions.
Annu Rev Cell Dev Biol
; 32: 279-301, 2016 10 06.
Article
em En
| MEDLINE
| ID: mdl-27298092
ABSTRACT
Inside eukaryotic cells, membrane contact sites (MCSs), regions where two membrane-bound organelles are apposed at less than 30 nm, generate regions of important lipid and calcium exchange. This review principally focuses on the structure and the function of MCSs between the endoplasmic reticulum (ER) and the plasma membrane (PM). Here we describe how tethering structures form and maintain these junctions and, in some instances, participate in their function. We then discuss recent insights into the mechanisms by which specific classes of proteins mediate nonvesicular lipid exchange between the ER and PM and how such phenomena, already known to be crucial for maintaining organelle identity, are also emerging as regulators of cell growth and development.
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Base de dados:
MEDLINE
Assunto principal:
Membrana Celular
/
Retículo Endoplasmático
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Cell Dev Biol
Assunto da revista:
BIOLOGIA
Ano de publicação:
2016
Tipo de documento:
Article