Urinary ß-2 Microglobulin Levels Sensitively Altered in an Osteomalacia Patient Receiving Add-on Adefovir Dipivoxil Therapy for Hepatitis B Virus Infection.
Intern Med
; 55(12): 1599-603, 2016.
Article
em En
| MEDLINE
| ID: mdl-27301512
ABSTRACT
Adefovir dipivoxil (ADV) is effective for hepatitis B virus (HBV) infection; however, ADV may provoke renal injury resulting in osteomalacia, and this side effect is seldom recognized until bone fractures emerge. We herein present a 66-year-old woman with HBV infection who received ADV for 6 years. Although she exhibited no sign of bone fractures, her urinary ß-2 microglobulin (ß2MG) level increased to 83,837 µg/L and scintigraphy revealed minimal fractures of the third rib. ADV was subsequently reduced and her urinary ß2MG rapidly fell to 3,637 µg/L. Conversely, her urinary N-acetyl-ß-D-glucosaminidase, and serum phosphate, alkaline phosphatase levels did not respond.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Osteomalacia
/
Adenina
/
Microglobulina beta-2
/
Hepatite B Crônica
/
Organofosfonatos
Tipo de estudo:
Diagnostic_studies
Limite:
Aged
/
Female
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Intern Med
Assunto da revista:
MEDICINA INTERNA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Japão