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A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification.
Goettsch, Claudia; Hutcheson, Joshua D; Hagita, Sumihiko; Rogers, Maximillian A; Creager, Michael D; Pham, Tan; Choi, Jung; Mlynarchik, Andrew K; Pieper, Brett; Kjolby, Mads; Aikawa, Masanori; Aikawa, Elena.
Afiliação
  • Goettsch C; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Hutcheson JD; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Hagita S; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Rogers MA; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Creager MD; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Pham T; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Choi J; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Mlynarchik AK; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Pieper B; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Kjolby M; The Lundbeck Foundation Research Center MIND, Danish Research Institute of Translational Neuroscience, Nordic EMBL Partnership for Molecular Medicine, Danish Diabetes Academy, Department of Biomedicine, Aarhus University, 8000, Denmark.
  • Aikawa M; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Center for Excellence in Vascular Biology, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Aikawa E; Center for Interdisciplinary Cardiovascular Sciences, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Center for Excellence in Vascular Biology, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Atherosclerosis ; 251: 109-118, 2016 08.
Article em En | MEDLINE | ID: mdl-27318830
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Calcinose / Pró-Proteína Convertase 9 / Mutação Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Atherosclerosis Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Calcinose / Pró-Proteína Convertase 9 / Mutação Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Atherosclerosis Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos