Simultaneous evaluation of substrate-dependent CYP3A inhibition using a CYP3A probe substrates cocktail.

Lee, Eunyoung; Shon, Jong Cheol; Liu, Kwang-Hyeon

Lee, Eunyoung; Shon, Jong Cheol; Liu, Kwang-Hyeon.

Afiliação

Lee E; BK21 Plus KNU Multi-Omics Based Creative Drug Research Team, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 41566, South Korea.
Shon JC; BK21 Plus KNU Multi-Omics Based Creative Drug Research Team, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 41566, South Korea.
Liu KH; BK21 Plus KNU Multi-Omics Based Creative Drug Research Team, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 41566, South Korea. dstlkh@knu.ac.kr.

Biopharm Drug Dispos ; 37(6): 366-72, 2016 Sep.

Article em En | MEDLINE | ID: mdl-27323294

Assuntos

Inibidores do Citocromo P-450 CYP3A/farmacologia; Citocromo P-450 CYP3A/metabolismo; Midazolam/farmacologia; Nifedipino/farmacologia; Testosterona/farmacologia; Descoberta de Drogas/métodos; Interações Medicamentosas; Humanos; Microssomos Hepáticos/metabolismo; Especificidade por Substrato

Palavras-chave

cytochrome P450; drug-drug interactions; mass spectrometry/MS

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Testosterona / Midazolam / Nifedipino / Citocromo P-450 CYP3A / Inibidores do Citocromo P-450 CYP3A Limite: Humans Idioma: En Revista: Biopharm Drug Dispos Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Coréia do Sul

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