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Clinical response to liposomal doxorubicin and rituximab in HHV-8-associated multicentric Castleman's disease in an HIV-positive patient.
Osa, Morichika; Maeda, Takuya; Misawa, Kazuhisa; Imai, Kazuo; Fujikura, Yuji; Kawana, Akihiko.
Afiliação
  • Osa M; Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
  • Maeda T; Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan; Department of Microbiology, Saitama Medical University, Saitama, Japan. Electronic address: t_maeda@saitama-med.ac.jp.
  • Misawa K; Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
  • Imai K; Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
  • Fujikura Y; Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
  • Kawana A; Division of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
J Infect Chemother ; 22(12): 804-807, 2016 Dec.
Article em En | MEDLINE | ID: mdl-27373909
ABSTRACT
We report a patient with HIV-associated multicentric Castleman's disease who had recurrent human herpesvirus-8 viremia associated with intermittent febrile exanthema and lymphadenopathy. Although the patient relapsed after single-agent treatment with liposomal doxorubicin, weekly infusions of rituximab led to complete remission even though the reactivation of the Kaposi's sarcoma was unfortunately observed. Rituximab could not only eliminate the accumulation of HHV-8 load but also play a part in the modulation of dysregulated CD20-positive B cells in HIV-associated multicentric Castleman's disease.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doxorrubicina / Infecções por HIV / Hiperplasia do Linfonodo Gigante / Herpesvirus Humano 8 / Rituximab Tipo de estudo: Risk_factors_studies Limite: Aged / Humans / Male Idioma: En Revista: J Infect Chemother Assunto da revista: MICROBIOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doxorrubicina / Infecções por HIV / Hiperplasia do Linfonodo Gigante / Herpesvirus Humano 8 / Rituximab Tipo de estudo: Risk_factors_studies Limite: Aged / Humans / Male Idioma: En Revista: J Infect Chemother Assunto da revista: MICROBIOLOGIA / TERAPIA POR MEDICAMENTOS Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Japão