A short and modular approach towards 3,5-disubstituted indolizidine alkaloids.
Org Biomol Chem
; 14(29): 7084-91, 2016 Aug 07.
Article
em En
| MEDLINE
| ID: mdl-27377480
ABSTRACT
3,5-Dialkyl indolizidines have been prepared in four linear steps from commercially available starting materials. The sequence involves two direct α-functionalization steps and a subsequent reductive amination and provides diastereoselective access to both C-3 epimers of the 5,9-trans-substituted indolizines. The naturally occurring indolizidines 195B and 223AB have been synthesized using this methodology.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Alcaloides
/
Indolizidinas
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Alemanha