Comparison of birth weights in patients randomly assigned to fresh or frozen-thawed embryo transfer.
Fertil Steril
; 106(2): 317-21, 2016 Aug.
Article
em En
| MEDLINE
| ID: mdl-27397626
ABSTRACT
OBJECTIVE:
To estimate birth weight differences between patients randomized to fresh or thawed ET.DESIGN:
Post hoc analysis of results from two similar randomized trials.SETTING:
Private fertility center. PATIENT(S) One hundred thirty-four first-time IVF patients, ages 18-40 years at oocyte retrieval, who had live birth. INTERVENTION(S) Patients were randomly assigned to have either fresh blastocyst transfer or all bipronuclear oocytes frozen followed by thaw, extended culture, and blastocyst transfer in a subsequent cycle. Preimplantation genetic screening was not allowed. MAIN OUTCOME MEASURE(S) Mean birth weight. RESULT(S) After allowing for the contributions of multiple significant variables (gestational age at birth, the presence of a vanished twin, number of infants delivered) in multiple linear regression, the adjusted mean birth weight was 166 g (95% confidence interval, 43-290 g) lower after fresh blastocyst transfer when compared with transfer of blastocysts derived from thawed bipronuclear oocytes. CONCLUSION(S) Birth weights are lower in cycles with fresh blastocyst transfer after controlled ovarian stimulation than in transfers of frozen-thawed embryos in the absence of ovarian stimulation. This finding confirms similar results reported in many retrospective studies. CLINICAL TRIAL REGISTRATION NUMBERS NCT00963625 and NCT00963079.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Indução da Ovulação
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Peso ao Nascer
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Blastocisto
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Fertilização in vitro
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Criopreservação
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Transferência Embrionária
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Infertilidade
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Newborn
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Pregnancy
Idioma:
En
Revista:
Fertil Steril
Ano de publicação:
2016
Tipo de documento:
Article