Design, synthesis and antiproliferative activity studies of novel dithiocarbamate-chalcone derivates.
Bioorg Med Chem Lett
; 26(16): 3918-22, 2016 08 15.
Article
em En
| MEDLINE
| ID: mdl-27423479
ABSTRACT
A series of novel dithiocarbamate-chalcone derivates were designed, synthesized and evaluated for antiproliferative activity against three selected cancer cell lines (EC-109, SK-N-SH and MGC-803). Majority of the synthesized compounds exhibited moderate to potent activity against all the cancer cell lines assayed. Particularly, compounds II2 and II5 exhibited the excellent growth inhibition against SK-N-SH with IC50 values of 2.03µM and 2.46µM, respectively. Further mechanism studies revealed that compound II2 could obviously inhibit the proliferation of SK-N-SH cells by inducing apoptosis and arresting the cell cycle at G0/G1 phase.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Tiocarbamatos
/
Desenho de Fármacos
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Chalcona
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Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2016
Tipo de documento:
Article