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Cutting Edge: B Cell-Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection.
Barnett, Burton E; Staupe, Ryan P; Odorizzi, Pamela M; Palko, Olesya; Tomov, Vesselin T; Mahan, Alison E; Gunn, Bronwyn; Chen, Diana; Paley, Michael A; Alter, Galit; Reiner, Steven L; Lauer, Georg M; Teijaro, John R; Wherry, E John.
Afiliação
  • Barnett BE; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104;
  • Staupe RP; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104;
  • Odorizzi PM; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104;
  • Palko O; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104; Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104;
  • Tomov VT; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104; Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104;
  • Mahan AE; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139;
  • Gunn B; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139;
  • Chen D; Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115;
  • Paley MA; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104;
  • Alter G; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139;
  • Reiner SL; Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032; Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032; and.
  • Lauer GM; Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115;
  • Teijaro JR; Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037.
  • Wherry EJ; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104; wherry@mail.med.upenn.edu.
J Immunol ; 197(4): 1017-22, 2016 08 15.
Article em En | MEDLINE | ID: mdl-27430722
ABSTRACT
The role of Ab and B cells in preventing infection is established. In contrast, the role of B cell responses in containing chronic infections remains poorly understood. IgG2a (IgG1 in humans) can prevent acute infections, and T-bet promotes IgG2a isotype switching. However, whether IgG2a and B cell-expressed T-bet influence the host-pathogen balance during persisting infections is unclear. We demonstrate that B cell-specific loss of T-bet prevents control of persisting viral infection. T-bet in B cells controlled IgG2a production, as well as mucosal localization, proliferation, glycosylation, and a broad transcriptional program. T-bet controlled a broad antiviral program in addition to IgG2a because T-bet in B cells was important, even in the presence of virus-specific IgG2a. Our data support a model in which T-bet is a universal controller of antiviral immunity across multiple immune lineages.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Subpopulações de Linfócitos B / Proteínas com Domínio T / Coriomeningite Linfocítica Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Immunol Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Subpopulações de Linfócitos B / Proteínas com Domínio T / Coriomeningite Linfocítica Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Immunol Ano de publicação: 2016 Tipo de documento: Article