[Association of heart valve calcification with cardiovascular outcomes in patients on maintenance hemodialysis].
Nan Fang Yi Ke Da Xue Xue Bao
; 36(7): 941-6, 2016 Jun 20.
Article
em Zh
| MEDLINE
| ID: mdl-27435773
ABSTRACT
OBJECTIVE:
To investigate the impact of heart valve calcification (HVC) on cardiovascular outcomes in patients on maintenance hemodialysis (MHD).METHODS:
We enrolled 302 Chinese patients on MHD between 2009 and 2011 including 99 with HVC identified by echocardiography screening. All the patients were followed up for 2 years and survival analysis was performed with all-cause mortality, cardiovascular mortality and new onset cardiovascular events as the endpoints. Cox regression analysis was used for analyzing the impact of heart valve calcification on the cardiovascular outcomes of the patients.RESULTS:
The mean age of the total patients was 58.2∓15.0 years when receiving the initial MHD, and 53.6% were male patients. The overall mortality, cardiovascular mortality and new on-set cardiovascular events in HVC and non-HVC groups were 30.3% vs 16.3%, 22.2% vs 6.9%, and 48.5% vs 25.6%, respectively (P<0.05). Kaplan-Meier survival analysis showed a significant difference in all-cause mortality (P=0.006), cardiovascular mortality (P<0.001) and new-onset cardiovascular events (P<0.001) between HVC and non-HVC groups. After adjustment, Cox regression analysis identified HVC as a risk factor for increased all-cause mortality (HR=1.88; 95%CI 1.11-3.19), cardiovascular mortality (HR=3.47, 95%CI 1.76-6.84) and cardiovascular events (HR=1.64, 95% CI 1.09-2.47).CONCLUSIONS:
HVC is an independent risk factor for increased cardiovascular mortality and new cardiovascular events in patients on MHD.
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Base de dados:
MEDLINE
Assunto principal:
Calcinose
/
Diálise Renal
/
Doenças das Valvas Cardíacas
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Nan Fang Yi Ke Da Xue Xue Bao
Ano de publicação:
2016
Tipo de documento:
Article