Pramipexole in the treatment of REM sleep behaviour disorder: A critical review.
Psychiatry Res
; 243: 365-72, 2016 Sep 30.
Article
em En
| MEDLINE
| ID: mdl-27449005
ABSTRACT
While widely accepted as a first-line treatment for rapid eye movement sleep (REM) behaviour disorder, clonazepam (CNZP) has side effects that limit its applicability. Pramipexole is a possible alternative, but limited literature on its effectiveness exists. This review aims to summarize the available data on the use of pramipexole in REM sleep behaviour disorder. A systematic search of major databases was conducted to look for published and on-going trials. This search yielded a total of five articles, all of which are observational in nature. Factors associated with effectiveness include low doses (less than 1.5mg/day) and idiopathic rapid eye movement sleep behaviour disorder/absence of neurodegenerative disease. Overall, the evidence is inconclusive. This is due to the lack of randomised controlled trials and the challenges in interpreting polysomgraphy findings in rapid eye movement sleep behaviour disorder. Suggestions are given on how future trials evaluating pramipexole treatment in rapid eye movement sleep behaviour disorder could overcome current methodological issues in extant literature.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Agonistas de Dopamina
/
Transtorno do Comportamento do Sono REM
/
Benzotiazóis
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
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Observational_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Psychiatry Res
Ano de publicação:
2016
Tipo de documento:
Article