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In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048).
Aaltonen, Niina; Kedzierska, Ewa; Orzelska-Górka, Jolanta; Lehtonen, Marko; Navia-Paldanius, Dina; Jakupovic, Hermina; Savinainen, Juha R; Nevalainen, Tapio; Laitinen, Jarmo T; Parkkari, Teija; Gynther, Mikko.
Afiliação
  • Aaltonen N; School of Medicine, Institute of Biomedicine/Physiology (N.A., D.N.-P., H.J., J.R.S., J.T.L.), and School of Pharmacy, (M.L., T.N., T.P., M.G.), University of Eastern Finland, Kuopio, Finland; and Department of Pharmacology and Pharmacodynamics, Faculty of Pharmacy with Division of Medical Analytics
  • Kedzierska E; School of Medicine, Institute of Biomedicine/Physiology (N.A., D.N.-P., H.J., J.R.S., J.T.L.), and School of Pharmacy, (M.L., T.N., T.P., M.G.), University of Eastern Finland, Kuopio, Finland; and Department of Pharmacology and Pharmacodynamics, Faculty of Pharmacy with Division of Medical Analytics
  • Orzelska-Górka J; School of Medicine, Institute of Biomedicine/Physiology (N.A., D.N.-P., H.J., J.R.S., J.T.L.), and School of Pharmacy, (M.L., T.N., T.P., M.G.), University of Eastern Finland, Kuopio, Finland; and Department of Pharmacology and Pharmacodynamics, Faculty of Pharmacy with Division of Medical Analytics
  • Lehtonen M; School of Medicine, Institute of Biomedicine/Physiology (N.A., D.N.-P., H.J., J.R.S., J.T.L.), and School of Pharmacy, (M.L., T.N., T.P., M.G.), University of Eastern Finland, Kuopio, Finland; and Department of Pharmacology and Pharmacodynamics, Faculty of Pharmacy with Division of Medical Analytics
  • Navia-Paldanius D; School of Medicine, Institute of Biomedicine/Physiology (N.A., D.N.-P., H.J., J.R.S., J.T.L.), and School of Pharmacy, (M.L., T.N., T.P., M.G.), University of Eastern Finland, Kuopio, Finland; and Department of Pharmacology and Pharmacodynamics, Faculty of Pharmacy with Division of Medical Analytics
  • Jakupovic H; School of Medicine, Institute of Biomedicine/Physiology (N.A., D.N.-P., H.J., J.R.S., J.T.L.), and School of Pharmacy, (M.L., T.N., T.P., M.G.), University of Eastern Finland, Kuopio, Finland; and Department of Pharmacology and Pharmacodynamics, Faculty of Pharmacy with Division of Medical Analytics
  • Savinainen JR; School of Medicine, Institute of Biomedicine/Physiology (N.A., D.N.-P., H.J., J.R.S., J.T.L.), and School of Pharmacy, (M.L., T.N., T.P., M.G.), University of Eastern Finland, Kuopio, Finland; and Department of Pharmacology and Pharmacodynamics, Faculty of Pharmacy with Division of Medical Analytics
  • Nevalainen T; School of Medicine, Institute of Biomedicine/Physiology (N.A., D.N.-P., H.J., J.R.S., J.T.L.), and School of Pharmacy, (M.L., T.N., T.P., M.G.), University of Eastern Finland, Kuopio, Finland; and Department of Pharmacology and Pharmacodynamics, Faculty of Pharmacy with Division of Medical Analytics
  • Laitinen JT; School of Medicine, Institute of Biomedicine/Physiology (N.A., D.N.-P., H.J., J.R.S., J.T.L.), and School of Pharmacy, (M.L., T.N., T.P., M.G.), University of Eastern Finland, Kuopio, Finland; and Department of Pharmacology and Pharmacodynamics, Faculty of Pharmacy with Division of Medical Analytics
  • Parkkari T; School of Medicine, Institute of Biomedicine/Physiology (N.A., D.N.-P., H.J., J.R.S., J.T.L.), and School of Pharmacy, (M.L., T.N., T.P., M.G.), University of Eastern Finland, Kuopio, Finland; and Department of Pharmacology and Pharmacodynamics, Faculty of Pharmacy with Division of Medical Analytics
  • Gynther M; School of Medicine, Institute of Biomedicine/Physiology (N.A., D.N.-P., H.J., J.R.S., J.T.L.), and School of Pharmacy, (M.L., T.N., T.P., M.G.), University of Eastern Finland, Kuopio, Finland; and Department of Pharmacology and Pharmacodynamics, Faculty of Pharmacy with Division of Medical Analytics
J Pharmacol Exp Ther ; 359(1): 62-72, 2016 10.
Article em En | MEDLINE | ID: mdl-27451409

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Inibidores Enzimáticos / Benzodioxóis / Monoacilglicerol Lipases Limite: Animals Idioma: En Revista: J Pharmacol Exp Ther Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Inibidores Enzimáticos / Benzodioxóis / Monoacilglicerol Lipases Limite: Animals Idioma: En Revista: J Pharmacol Exp Ther Ano de publicação: 2016 Tipo de documento: Article