Cilostazol Modulates Autophagic Degradation of ß-Amyloid Peptide via SIRT1-Coupled LKB1/AMPK&#945; Signaling in Neuronal Cells.

Park, So Youn; Lee, Hye Rin; Lee, Won Suk; Shin, Hwa Kyoung; Kim, Hye Young; Hong, Ki Whan; Kim, Chi Dae

Cilostazol Modulates Autophagic Degradation of ß-Amyloid Peptide via SIRT1-Coupled LKB1/AMPKα Signaling in Neuronal Cells.

Park, So Youn; Lee, Hye Rin; Lee, Won Suk; Shin, Hwa Kyoung; Kim, Hye Young; Hong, Ki Whan; Kim, Chi Dae.

Afiliação

Park SY; Department of Pharmacology, School of Korean Medicine, Pusan National University, Gyeongsangnam-do, 50612, Republic of Korea.
Lee HR; Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, 50612, Republic of Korea.
Lee WS; Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, 50612, Republic of Korea.
Shin HK; Department of Pharmacology, School of Korean Medicine, Pusan National University, Gyeongsangnam-do, 50612, Republic of Korea.
Kim HY; Division of Meridian and Structural Medicine, Pusan National University, Gyeongsangnam-do, 50612, Republic of Korea.
Hong KW; Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, 50612, Republic of Korea.
Kim CD; Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Gyeongsangnam-do, 50612, Republic of Korea.

PLoS One ; 11(8): e0160620, 2016.

Article em En | MEDLINE | ID: mdl-27494711

Assuntos

Proteínas Quinases Ativadas por AMP/metabolismo; Peptídeos beta-Amiloides/metabolismo; Neuroblastoma/patologia; Proteínas Serina-Treonina Quinases/metabolismo; Proteólise/efeitos dos fármacos; Sirtuína 1/metabolismo; Tetrazóis/farmacologia; Precursor de Proteína beta-Amiloide/metabolismo; Animais; Autofagia/efeitos dos fármacos; Cilostazol; Humanos; Neuroblastoma/tratamento farmacológico; Neuroblastoma/metabolismo; Fármacos Neuroprotetores/farmacologia; Transdução de Sinais/efeitos dos fármacos; Células Tumorais Cultivadas

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tetrazóis / Peptídeos beta-Amiloides / Proteínas Serina-Treonina Quinases / Proteínas Quinases Ativadas por AMP / Sirtuína 1 / Proteólise / Neuroblastoma Limite: Animals / Humans Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2016 Tipo de documento: Article

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