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[Economic evaluation on different two-dose-vaccination-strategies related to Measles, Mumps and Rubella Combined Attenuated Live Vaccine].
He, H Q; Zhang, B; Yan, R; Li, Q; Fu, J; Tang, X W; Zhou, Y; Deng, X; Xie, S Y.
Afiliação
  • He HQ; Expanded Program Immunization Department of Zhejiang Provincial Center for Diseases Control and Prevention, Hangzhou 310051, China.
Zhonghua Liu Xing Bing Xue Za Zhi ; 37(8): 1121-6, 2016 Aug 10.
Article em Zh | MEDLINE | ID: mdl-27539345
ABSTRACT

OBJECTIVE:

To evaluate the economic effect of Measles, Mumps and Rubella Combined Attenuated Live Vaccine (MMR) under different two-dose vaccination programs.

METHODS:

A hypothetical birth cohort of 750 000 infants over their lifetime, was followed up from birth through death in Zhejiang province. The current MMR vaccination strategie would include three different ones 1) Childlern were vaccinated with Measles-Rubella Combined Attenuated Live Vaccine and MMR, respectively at the age of 8 months and 18 months. 2) Children receive MMR at 8 months and 18 months, 3) Strategy 1 plus an additional vaccination of MMR at 4 years of age. Incremental cost-effectiveness ratio (ICER), incremental cost-benefit ratio (ICBR) and incremental net benefit (INB) were applied to calculate the health economic difference for Strategy 2 and Strategy 3 as compared to Strategy 1. Univariate sensitivity analysis was used to assess the robustness of results with main parameters, including the rate of immunization coverage, effectiveness of the vaccines, incidence and burdens of the related diseases, cost of vaccines and the vaccination program itself.

RESULTS:

ICER, ICBR and INB for Strategy 2 and Strategy 3 appeared as 2 012.51∶1 RMB Yuan per case and 4 238.72∶1 RMB Yuan per case, 1∶3.14 and 1∶1.58, 21 277 800 RMB Yuan and 9 276 500 RMB Yuan, respectively. Only slight changes (<20%) were found under the univariate sensitivity analysis, with varied values on main parameters.

CONCLUSION:

Based on the current national immunization program, infants vaccinated with MMR at 8 months of age, generated more health economic effects than the Strategy 3.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rubéola (Sarampo Alemão) / Vacinas Atenuadas / Análise Custo-Benefício / Programas de Imunização / Vacina contra Sarampo-Caxumba-Rubéola / Sarampo / Caxumba Tipo de estudo: Evaluation_studies / Health_economic_evaluation Limite: Adolescent / Adult / Child / Child, preschool / Humans / Infant Idioma: Zh Revista: Zhonghua Liu Xing Bing Xue Za Zhi Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rubéola (Sarampo Alemão) / Vacinas Atenuadas / Análise Custo-Benefício / Programas de Imunização / Vacina contra Sarampo-Caxumba-Rubéola / Sarampo / Caxumba Tipo de estudo: Evaluation_studies / Health_economic_evaluation Limite: Adolescent / Adult / Child / Child, preschool / Humans / Infant Idioma: Zh Revista: Zhonghua Liu Xing Bing Xue Za Zhi Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China