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Cholinergic System and Neuroinflammation: Implication in Multiple Sclerosis.
Di Bari, Maria; Di Pinto, Giovanni; Reale, Marcella; Mengod, Guadalupe; Tata, Ada Maria.
Afiliação
  • Di Bari M; Department of Biology and Biotechnologies C. Darwin, Research Center of Neurobiology Daniel Bovet, "Sapienza" University of Rome, Italy.
  • Di Pinto G; IIBB-CSIC, IDIBAPS, CIBERNED, Barcelona, Spain.
  • Reale M; Department of Biology and Biotechnologies C. Darwin, Research Center of Neurobiology Daniel Bovet, "Sapienza" University of Rome, Italy.
  • Mengod G; IIBB-CSIC, IDIBAPS, CIBERNED, Barcelona, Spain.
  • Tata AM; Department of Medical, Oral and Biotechnological Science, University "G. d'Annunzio" Chieti-Pescara, Pescara, Italy.
Cent Nerv Syst Agents Med Chem ; 17(2): 109-115, 2017.
Article em En | MEDLINE | ID: mdl-27550615
BACKGROUND: Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS) characterized by leucocytes infiltration, demyelination, axonal degeneration and neuronal death. Although the etiology of MS is still unkwon, inflammation and autoimmunity are considered to be key players of the disease. Nervous System: The severe alterations affecting the nervous system contribute to the motor and cognitive disabilities and are in large part dependent on severe inflammatory processes active in both central nervous system and immune system. Acetylcholine (ACh) appears to be involved in the modulation of central and peripheral inflammation. Immune cells as well as astrocytes and microglia respond to ACh stimuli by activation of cholinergic receptors. Muscarinic and nicotinic receptors differently contribute to the modulation of immunological and inflammatory processes stimulating pro- and anti-inflammatory cytokines respectively. The role played by ACh in MS is not yet fully understood, although some results point to its involvement in different neurological disorders such as Alzheimer's disease and schizophrenia. CONCLUSION: In the present review we summarize the evidence indicating the correlation between nervous system dysfunction in MS, with inflammation and cholinergic system alterations. Experiments performed in MS animal models and analyses on biological fluids from MS patients such as blood, serum and cerebrospinal fluid suggest that cholinergic alterations may contribute to the dysregulated inflammatory processes of MS. Many current therapeutic approaches in MS are based on anti-inflammatory drugs. We also discuss how the use of cholinesterase inhibitors or ACh mimetics may represent a new interesting therapeutic approach in MS.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores da Colinesterase / Mediadores da Inflamação / Colinérgicos / Anti-Inflamatórios / Esclerose Múltipla Limite: Animals / Humans Idioma: En Revista: Cent Nerv Syst Agents Med Chem Assunto da revista: FARMACOLOGIA / NEUROLOGIA / QUIMICA CLINICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores da Colinesterase / Mediadores da Inflamação / Colinérgicos / Anti-Inflamatórios / Esclerose Múltipla Limite: Animals / Humans Idioma: En Revista: Cent Nerv Syst Agents Med Chem Assunto da revista: FARMACOLOGIA / NEUROLOGIA / QUIMICA CLINICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Itália