Pictilisib PI3Kinase inhibitor (a phosphatidylinositol 3-kinase [PI3K] inhibitor) plus paclitaxel for the treatment of hormone receptor-positive, HER2-negative, locally recurrent, or metastatic breast cancer: interim analysis of the multicentre, placebo-controlled, phase II randomised PEGGY study.

Vuylsteke, P; Huizing, M; Petrakova, K; Roylance, R; Laing, R; Chan, S; Abell, F; Gendreau, S; Rooney, I; Apt, D; Zhou, J; Singel, S; Fehrenbacher, L

Vuylsteke, P; Huizing, M; Petrakova, K; Roylance, R; Laing, R; Chan, S; Abell, F; Gendreau, S; Rooney, I; Apt, D; Zhou, J; Singel, S; Fehrenbacher, L.

Afiliação

Vuylsteke P; Department of Medical Oncology, Université Catholique de Louvain, CHU UCL Namur, Sainte-Elisabeth peter.vuylsteke@cmsenamur.be.
Huizing M; Multidisciplinary Breast and Gynaecological Oncology Unit, Universitair Ziekenhuis Antwerpen, Antwerp, Belgium.
Petrakova K; Department of Medical Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Roylance R; Department of Medical Oncology, Barts Health NHS Trust and Barts Cancer Institute, Queen Mary University of London, London.
Laing R; Department of Oncology, The Royal Surrey County Hospital, Guildford.
Chan S; Department of Clinical Oncology, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Abell F; Department of Medical Oncology, Calvary Mater Hospital Newcastle, New South Wales, Australia.
Gendreau S; Oncology Biomarker Development.
Rooney I; Product Development Oncology.
Apt D; BioOncology.
Zhou J; Product Development Biometrics Biostatistics Department, Genentech Inc., South San Francisco, USA.
Singel S; Product Development Oncology.
Fehrenbacher L; Kaiser Permanente, Northern California, Vallejo, CA, USA.

Ann Oncol ; 27(11): 2059-2066, 2016 11.

Article em En | MEDLINE | ID: mdl-27573562

Assuntos

Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem; Neoplasias da Mama/tratamento farmacológico; Classe I de Fosfatidilinositol 3-Quinases/genética; Indazóis/administração & dosagem; Recidiva Local de Neoplasia/tratamento farmacológico; Sulfonamidas/administração & dosagem; Adulto; Idoso; Anticorpos Monoclonais Humanizados/administração & dosagem; Neoplasias da Mama/genética; Neoplasias da Mama/patologia; Classe I de Fosfatidilinositol 3-Quinases/antagonistas & inibidores; Intervalo Livre de Doença; Feminino; Humanos; Pessoa de Meia-Idade; Metástase Neoplásica; Recidiva Local de Neoplasia/genética; Recidiva Local de Neoplasia/patologia; Paclitaxel/administração & dosagem; Receptor ErbB-2/genética

Palavras-chave

HER2-negative; PI3K; PIK3CA; hormone receptor-positive; metastatic breast cancer; pictilisib

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Base de dados: MEDLINE Assunto principal: Sulfonamidas / Neoplasias da Mama / Protocolos de Quimioterapia Combinada Antineoplásica / Classe I de Fosfatidilinositol 3-Quinases / Indazóis / Recidiva Local de Neoplasia Tipo de estudo: Clinical_trials / Guideline Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Ann Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2016 Tipo de documento: Article

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