Human paraoxonase gene cluster overexpression alleviates angiotensin II-induced cardiac hypertrophy in mice.

Pei, Jian-Fei; Yan, Yun-Fei; Tang, Xiaoqiang; Zhang, Yang; Cui, Shen-Shen; Zhang, Zhu-Qin; Chen, Hou-Zao; Liu, De-Pei

Pei, Jian-Fei; Yan, Yun-Fei; Tang, Xiaoqiang; Zhang, Yang; Cui, Shen-Shen; Zhang, Zhu-Qin; Chen, Hou-Zao; Liu, De-Pei.

Afiliação

Pei JF; State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Yan YF; State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Tang X; State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Zhang Y; State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Cui SS; State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Zhang ZQ; State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.
Chen HZ; State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China. chenhouzao@ibms.cams.cn.
Liu DP; State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China. liudp@pumc.edu.cn.

Sci China Life Sci ; 59(11): 1115-1122, 2016 Nov.

Article em En | MEDLINE | ID: mdl-27578362

Assuntos

Arildialquilfosfatase/metabolismo; Cardiomegalia/enzimologia; Angiotensina II; Animais; Arildialquilfosfatase/genética; Pressão Sanguínea/genética; Western Blotting; Cardiomegalia/induzido quimicamente; Cardiomegalia/genética; Ecocardiografia; Fibrose/enzimologia; Fibrose/genética; Regulação Enzimológica da Expressão Gênica; Coração/fisiopatologia; Humanos; Masculino; Metaloproteinases da Matriz/metabolismo; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Família Multigênica; Miocárdio/enzimologia; Miocárdio/metabolismo; Miocárdio/patologia; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Inibidores Teciduais de Metaloproteinases/metabolismo; Remodelação Ventricular/genética

Palavras-chave

angiotensin II; cardiac hypertrophy; fibrosis; paraoxonase gene cluster

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Base de dados: MEDLINE Assunto principal: Cardiomegalia / Arildialquilfosfatase Limite: Animals / Humans / Male Idioma: En Revista: Sci China Life Sci Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China

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