The effect of hyperglycemia on blood coagulation: In vitro, observational healthy-volunteer study using rotational thromboelastometry (ROTEM).
Medicine (Baltimore)
; 95(35): e4703, 2016 Aug.
Article
em En
| MEDLINE
| ID: mdl-27583903
ABSTRACT
We performed a study to investigate whether contamination of hemostasis samples with a glucose-containing solution might generate spurious results in rotational thromboelastometry (ROTEM) tests.Venous blood was taken from 12 healthy volunteers and divided into 4 specimen bottles, which were contaminated with different concentrations (0%, 5%, 10%, and 20%) of glucose solution.Significant lengthening of INTEMCT was observed in the 10% and 20% groups compared with baseline values (7.7% and 9%, Pâ=â0.041 and Pâ=â0.037, respectively). INTEMCFT increased by 20.1% in the 20% group (Pâ=â0.005). INTEMα-angle and INTEMMCF decreased by 3.9% and 2.7%, respectively, in the 20% group (Pâ=â0.010 and Pâ=â0.049, respectively). EXTEMCFT was prolonged significantly, by 10.2%, 15.5%, and 25.6%, in the 5%, 10%, and 20% groups, respectively (Pâ=â0.004, Pâ<â0.001, and Pâ<â0.001, respectively). EXTEMα-angle decreased significantly by 1.9%, 3.2%, and 4.0% in the 5%, 10%, and 20% groups, respectively (Pâ=â0.014, Pâ=â0.001, and Pâ=â0.005, respectively). EXTEMMCF decreased by 3.4% in the 20% group (Pâ=â0.023). FIBTEMMCF decreased by 9.2% and 17.5% in the 10% and 20% groups, respectively (Pâ=â0.019 and Pâ=â0.021, respectively). A significant correlation was observed between standard glucose solution contamination in the specimens and percentage variation of EXTEMCFT, EXTEMMCF, and FIBTEMMCF.To obtain accurate data from the ROTEM test regarding the hemostatic status of patients, specimens with suspected or known contamination should not be analyzed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tromboelastografia
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Coagulação Sanguínea
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Glicemia
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Coleta de Amostras Sanguíneas
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Hidratação
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Glucose
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Coréia do Sul