Region-specific roles of the corticotropin-releasing factor-urocortin system in stress.
Nat Rev Neurosci
; 17(10): 636-51, 2016 10.
Article
em En
| MEDLINE
| ID: mdl-27586075
ABSTRACT
Dysregulation of the corticotropin-releasing factor (CRF)-urocortin (UCN) system has been implicated in stress-related psychopathologies such as depression and anxiety. It has been proposed that CRF-CRF receptor type 1 (CRFR1) signalling promotes the stress response and anxiety-like behaviour, whereas UCNs and CRFR2 activation mediate stress recovery and the restoration of homeostasis. Recent findings, however, provide clear evidence that this view is overly simplistic. Instead, a more complex picture has emerged that suggests that there are brain region- and cell type-specific effects of CRFR signalling that are influenced by the individual's prior experience and that shape molecular, cellular and ultimately behavioural responses to stressful challenges.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ansiedade
/
Estresse Psicológico
/
Hormônio Liberador da Corticotropina
/
Receptores de Hormônio Liberador da Corticotropina
/
Depressão
/
Urocortinas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Israel