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Age-adjusted plasma N-terminal pro-brain natriuretic peptide level in Kawasaki disease.
Jun, Heul; Ko, Kyung Ok; Lim, Jae Woo; Yoon, Jung Min; Lee, Gyung Min; Cheon, Eun Jung.
Afiliação
  • Jun H; Department of Pediatrics, Konyang University College of Medicine, Daejon, Korea.
  • Ko KO; Department of Pediatrics, Konyang University College of Medicine, Daejon, Korea.
  • Lim JW; Department of Pediatrics, Konyang University College of Medicine, Daejon, Korea.
  • Yoon JM; Department of Pediatrics, Konyang University College of Medicine, Daejon, Korea.
  • Lee GM; Department of Pediatrics, Konyang University College of Medicine, Daejon, Korea.
  • Cheon EJ; Department of Pediatrics, Konyang University College of Medicine, Daejon, Korea.
Korean J Pediatr ; 59(7): 298-302, 2016 Jul.
Article em En | MEDLINE | ID: mdl-27588030
ABSTRACT

PURPOSE:

Recent reports showed that plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) could be a useful biomarker of intravenous immunoglobulin (IVIG) unresponsiveness and coronary artery lesion (CAL) development in Kawasaki disease (KD). The levels of these peptides are critically influenced by age; hence, the normal range and upper limits for infants and children are different. We performed an age-adjusted analysis of plasma NT-proBNP level to validate its clinical use in the diagnosis of KD.

METHODS:

The data of 131 patients with KD were retrospectively analyzed. The patients were divided into 2 groups-group I (high NT-proBNP group) and group II (normal NT-proBNP group)-comprising patients with NT-proBNP concentrations higher and lower than the 95th percentile of the reference value, respectively. We compared the laboratory data, responsiveness to IVIG, and the risk of CAL in both groups.

RESULTS:

Group I showed significantly higher white blood cell count, absolute neutrophil count, C-reactive protein level, aspartate aminotransferase level, and troponin-I level than group II (P<0.05). The risk of CAL was also significantly higher in group I (odds ratio, 5.78; P=0.012). IVIG unresponsiveness in group I was three times that in group II (odds ratio, 3.35; P= 0.005).

CONCLUSION:

Age-adjusted analysis of plasma NT-proBNP level could be helpful in predicting IVIG unresponsiveness and risk of CAL development in patients with KD.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Korean J Pediatr Ano de publicação: 2016 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Korean J Pediatr Ano de publicação: 2016 Tipo de documento: Article