Effects of Physical Activity Intervention on Physical and Cognitive Function in Sedentary Adults With and Without Diabetes.
J Gerontol A Biol Sci Med Sci
; 72(6): 861-866, 2017 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-27590629
ABSTRACT
BACKGROUND:
Type 2 diabetes mellitus may alter the effect of physical activity on physical and cognitive function.METHODS:
The Lifestyle Interventions and Independence for Elders (LIFE) trial randomized controlled clinical trial of physical activity intervention (walking, resistance training, and flexibility exercises) enrolled adults aged 70-89 years who were sedentary and non-demented and who had functional limitations. Standardized measures of physical and cognitive function were collected an average of 2 years post-randomization. Differences between the intervention and control groups from 415 individuals with diabetes and 1,061 individuals without diabetes were contrasted with analyses of covariance.RESULTS:
At 24 months, assignment to the physical activity intervention resulted in 0.019 m/s relatively faster average 400-meter gait speeds (p = .007 overall) both for individuals with and without diabetes (intervention × diabetes interaction p = .99). No benefits were seen on scores from a physical performance battery. Performance on cognitive tests was better among participants assigned to the physical activity intervention compared with control only for those with diabetes, particularly for global cognitive function (p = .02) and delayed memory (p = .005), with mean [95% confidence intervals] for benefit from physical activity intervention of 0.114 [0.007,0.111] and 0.208 [0.030,0.387] standard deviations, respectively.CONCLUSIONS:
Physical activity intervention improved the gait speed of older, sedentary individuals with and without diabetes. The cognitive function benefits occurred among participants with, but not without, diabetes. The mechanisms through which physical activity affects physical and cognitive function in older adults may differ for individuals by diabetes status.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Exercício Físico
/
Cognição
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Diabetes Mellitus Tipo 2
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Comportamento Sedentário
/
Velocidade de Caminhada
Tipo de estudo:
Clinical_trials
Limite:
Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
J Gerontol A Biol Sci Med Sci
Assunto da revista:
GERIATRIA
Ano de publicação:
2017
Tipo de documento:
Article