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Penicilazaphilone C, a new antineoplastic and antibacterial azaphilone from the Marine Fungus Penicillium sclerotiorum.
Zhou, Song-Lin; Wang, Min; Zhao, Huan-Ge; Huang, Yong-Hao; Lin, Ying-Ying; Tan, Guang-Hong; Chen, Shung-Lin.
Afiliação
  • Zhou SL; Key Laboratory of Translation Medicine for Tropical Diseases, Ministry of Education, Hainan Medical College, Haikou, 571199, China.
  • Wang M; Hainan Provincial Key Laboratory of Tropical Medicine, Hainan Medical College, Haikou, 571199, China.
  • Zhao HG; College of Life Sciences, Nanjing Normal University, Nanjing, 210046, China.
  • Huang YH; Key Laboratory of Translation Medicine for Tropical Diseases, Ministry of Education, Hainan Medical College, Haikou, 571199, China.
  • Lin YY; Hainan Provincial Key Laboratory of Tropical Medicine, Hainan Medical College, Haikou, 571199, China.
  • Tan GH; Key Laboratory of Translation Medicine for Tropical Diseases, Ministry of Education, Hainan Medical College, Haikou, 571199, China.
  • Chen SL; Hainan Provincial Key Laboratory of Tropical Medicine, Hainan Medical College, Haikou, 571199, China.
Arch Pharm Res ; 39(12): 1621-1627, 2016 Dec.
Article em En | MEDLINE | ID: mdl-27605109
Two azaphilonidal derivatives [penicilazaphilones B (1) and C (2)], have been isolated from the fermented products of marine fungus strain Penicillium sclerotiorum M-22, penicilazaphilones C was a new compound. The compound's structures were identified by the analysis of spectroscopic data including 1D and 2D NMR techniques (1H-NMR, 13C-NMR, COSY, HMQC, and HMBC). Biological evaluation revealed that penicilazaphilones B and C showed selective cytotoxicity against melanoma cells B-16 and human gastric cancer cells SGC-7901 with IC50 values of 0.291, 0.449 and 0.065, 0.720 mM, respectively, while exhibiting no significant toxicity to normal mammary epithelial cells M10 at the same concentration. Moreover, penicilazaphilones C also exhibited strong antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia and Escherichia coli with MIC values 0.037-0.150 mM, while penicilazaphilones B's bacteriostatic action was weaker.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Penicillium / Pigmentos Biológicos / Benzopiranos / Antibacterianos / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Arch Pharm Res Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Penicillium / Pigmentos Biológicos / Benzopiranos / Antibacterianos / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Arch Pharm Res Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China