Induced Regulatory T Cells: Their Development, Stability, and Applications.
Trends Immunol
; 37(11): 803-811, 2016 11.
Article
em En
| MEDLINE
| ID: mdl-27623114
ABSTRACT
Regulatory T (Treg) cells, as central mediators of immune suppression, play crucial roles in many facets of immune systems. The transcription factor Foxp3 has been characterized as a master regulator of Tregs, and is induced during their thymic development. Foxp3+ Tregs can also be generated from naïve T cells after stimulation in the presence of TGF-ß and IL-2; the resulting cells are called induced Tregs (iTregs) when generated in vitro, or peripheral Tregs (pTregs) when generated in vivo. Compared to tTregs, iTregs have been shown to be unstable, and attempts to generate stable iTregs have been made for clinical applications. We review here the current knowledge on the development of pTregs, iTregs, and their roles and applications.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Timo
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Imunoterapia Adotiva
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Subpopulações de Linfócitos T
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Linfócitos T Reguladores
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Fatores de Transcrição Forkhead
Limite:
Animals
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Humans
Idioma:
En
Revista:
Trends Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Japão