Dehydroretronecine-induced skin tumors in mice.
J Natl Cancer Inst
; 61(1): 85-9, 1978 Jul.
Article
em En
| MEDLINE
| ID: mdl-276619
ABSTRACT
Female Swiss mice susceptible to skin tumors received 6 sc injections and/or topical applications of dehydroretronecine, a metabolite of the pyrrolizidine alkaloid monocrotaline, and were observed for 15 months for tumor development. Of 92 animals examined, 63 had tumors at the site of application or injection; 47 of these had skin tumors, mainly basal cell and squamous cell carcinomas. These data indicate that dehydroretronecine is a proximate carcinogen capable of causing a high incidence of skin tumours in mice at the site of sc injection or topical application.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Alcaloides de Pirrolizidina
/
Neoplasias Cutâneas
/
Carcinoma Basocelular
/
Carcinoma de Células Escamosas
Limite:
Animals
Idioma:
En
Revista:
J Natl Cancer Inst
Ano de publicação:
1978
Tipo de documento:
Article