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Availability of sentinel lymph node biopsy for cutaneous squamous cell carcinoma.
Maruyama, Hiroshi; Tanaka, Ryota; Fujisawa, Yasuhiro; Nakamura, Yasuhiro; Ito, Shusaku; Fujimoto, Manabu.
Afiliação
  • Maruyama H; Division of Clinical Medicine, Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Tanaka R; Division of Clinical Medicine, Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Fujisawa Y; Division of Clinical Medicine, Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Nakamura Y; Department of Skin Oncology/Dermatology, Saitama Medical University International Medical Center, Saitama, Japan.
  • Ito S; Department of Dermatology, Hitachi General Hospital, Hitachi, Japan.
  • Fujimoto M; Division of Clinical Medicine, Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
J Dermatol ; 44(4): 431-437, 2017 Apr.
Article em En | MEDLINE | ID: mdl-27666747
ABSTRACT
Cutaneous squamous cell carcinoma is the second common cutaneous cancer, especially in the elderly. Sentinel lymph node biopsy is generally performed in breast cancers and cutaneous melanomas to detect occult nodal metastases. The benefit of sentinel lymph node biopsy in improving cutaneous squamous cell carcinoma prognosis is doubtful. One hundred and sixty-nine patients who underwent treatment for cutaneous squamous cell carcinoma between 2004 and 2015, and who were followed up for at least 6 months or developed metastases within the follow-up period were included. Forty-nine patients underwent sentinel lymph node biopsy, whereas 120 patients did not, including 13 who exhibited clinical lymph node metastases before treatment. Of these 49 patients, nine (18.4%) presented with sentinel lymph node metastasis, which occurred after treatment in three (6.1%) of them (false-negative). Among the 107 patients who did not undergo lymph node biopsy, 12 (11.2%) developed post-treatment metastases. The metastasis-free and disease-specific survival rates were not significantly different in those who did or did not undergo sentinel lymph node biopsy. Patients with clinical lymph node metastases had a higher risk compared with those without. Patients with T2-T4 tumors had a higher risk compared with those with T1 tumors. When selecting for those with T2 tumors or greater, the same lack of relationship was observed. In conclusion, in this small retrospective cohort, in patients with cutaneous squamous cell carcinoma, there were no significant differences in metastasis-free and disease-specific survival rates between those who did or did not undergo sentinel lymph node biopsy, regardless of T staging.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Carcinoma de Células Escamosas / Biópsia de Linfonodo Sentinela / Linfonodo Sentinela Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Dermatol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Carcinoma de Células Escamosas / Biópsia de Linfonodo Sentinela / Linfonodo Sentinela Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Dermatol Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Japão