PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier.

Rom, Slava; Zuluaga-Ramirez, Viviana; Reichenbach, Nancy L; Dykstra, Holly; Gajghate, Sachin; Pacher, Pal; Persidsky, Yuri

Rom, Slava; Zuluaga-Ramirez, Viviana; Reichenbach, Nancy L; Dykstra, Holly; Gajghate, Sachin; Pacher, Pal; Persidsky, Yuri.

Afiliação

Rom S; Department of Pathology and Laboratory Medicine, Temple University, Philadelphia, PA, 19140, USA. srom@temple.edu.
Zuluaga-Ramirez V; Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA. srom@temple.edu.
Reichenbach NL; Department of Pathology and Laboratory Medicine, Temple University, Philadelphia, PA, 19140, USA.
Dykstra H; Department of Pathology and Laboratory Medicine, Temple University, Philadelphia, PA, 19140, USA.
Gajghate S; Department of Pathology and Laboratory Medicine, Temple University, Philadelphia, PA, 19140, USA.
Pacher P; Department of Pathology and Laboratory Medicine, Temple University, Philadelphia, PA, 19140, USA.
Persidsky Y; Laboratory of Cardiovascular Physiology and Tissue Injury, National Institutes of Health/NIAAA, Bethesda, MD, 20852, USA.

J Neuroinflammation ; 13(1): 254, 2016 Sep 27.

Article em En | MEDLINE | ID: mdl-27677851

Palavras-chave

Actin cytoskeleton; LFA-1; Leukocyte-endothelial interaction; PARP-1; VLA-4

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: J Neuroinflammation Assunto da revista: NEUROLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

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