Transcriptional activity of human endogenous retrovirus in Albanian children with autism spectrum disorders.
New Microbiol
; 39(3): 228-231, 2016 Jul.
Article
em En
| MEDLINE
| ID: mdl-27704145
ABSTRACT
Recent studies suggest that autism spectrum disorders (ASD) result from interactions between genetic and environmental factors, whose possible links could be represented by epigenetic mechanisms. Here, we investigated the transcriptional activity of three human endogenous retrovirus (HERV) families, in peripheral blood mononuclear cells (PBMCs) from Albanian ASD children, by quantitative real-time PCR. We aimed to confirm the different expression profile already found in Italian ASD children, and to highlight any social and family health condition emerging from information gathered through a questionnaire, to be included among environmental risk factors. The presence of increased HERV-H transcriptional activity in all autistic patients could be understood as a constant epigenetic imprinting of the disease, potentially useful for early diagnosis and for the development of effective novel therapeutic strategies.
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Base de dados:
MEDLINE
Assunto principal:
Regulação Viral da Expressão Gênica
/
Retrovirus Endógenos
/
Transtorno do Espectro Autista
Tipo de estudo:
Risk_factors_studies
/
Screening_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
New Microbiol
Assunto da revista:
MICROBIOLOGIA
Ano de publicação:
2016
Tipo de documento:
Article