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Common epigenetic variation in a European population of mentally healthy young adults.
Milnik, Annette; Vogler, Christian; Demougin, Philippe; Egli, Tobias; Freytag, Virginie; Hartmann, Francina; Heck, Angela; Peter, Fabian; Spalek, Klara; Stetak, Attila; de Quervain, Dominique J-F; Papassotiropoulos, Andreas; Vukojevic, Vanja.
Afiliação
  • Milnik A; Division of Molecular Neuroscience, Department of Psychology, University of Basel, CH-4055, Basel, Switzerland; Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, CH-4055, Basel, Switzerland; Psychiatric University Clinics, University of Basel, CH-4055, Basel,
  • Vogler C; Division of Molecular Neuroscience, Department of Psychology, University of Basel, CH-4055, Basel, Switzerland; Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, CH-4055, Basel, Switzerland; Psychiatric University Clinics, University of Basel, CH-4055, Basel,
  • Demougin P; Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, CH-4055, Basel, Switzerland; Department Biozentrum, Life Sciences Training Facility, University of Basel, CH-4056, Basel, Switzerland.
  • Egli T; Division of Molecular Neuroscience, Department of Psychology, University of Basel, CH-4055, Basel, Switzerland; Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, CH-4055, Basel, Switzerland.
  • Freytag V; Division of Molecular Neuroscience, Department of Psychology, University of Basel, CH-4055, Basel, Switzerland; Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, CH-4055, Basel, Switzerland.
  • Hartmann F; Division of Molecular Neuroscience, Department of Psychology, University of Basel, CH-4055, Basel, Switzerland; Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, CH-4055, Basel, Switzerland.
  • Heck A; Division of Molecular Neuroscience, Department of Psychology, University of Basel, CH-4055, Basel, Switzerland; Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, CH-4055, Basel, Switzerland; Psychiatric University Clinics, University of Basel, CH-4055, Basel,
  • Peter F; Division of Molecular Neuroscience, Department of Psychology, University of Basel, CH-4055, Basel, Switzerland; Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, CH-4055, Basel, Switzerland; Department Biozentrum, Life Sciences Training Facility, University o
  • Spalek K; Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, CH-4055, Basel, Switzerland; Division of Cognitive Neuroscience, Department of Psychology, University of Basel, CH-4055, Basel, Switzerland.
  • Stetak A; Division of Molecular Neuroscience, Department of Psychology, University of Basel, CH-4055, Basel, Switzerland; Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, CH-4055, Basel, Switzerland; Psychiatric University Clinics, University of Basel, CH-4055, Basel,
  • de Quervain DJ; Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, CH-4055, Basel, Switzerland; Psychiatric University Clinics, University of Basel, CH-4055, Basel, Switzerland; Division of Cognitive Neuroscience, Department of Psychology, University of Basel, CH-4055, Basel,
  • Papassotiropoulos A; Division of Molecular Neuroscience, Department of Psychology, University of Basel, CH-4055, Basel, Switzerland; Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, CH-4055, Basel, Switzerland; Psychiatric University Clinics, University of Basel, CH-4055, Basel,
  • Vukojevic V; Division of Molecular Neuroscience, Department of Psychology, University of Basel, CH-4055, Basel, Switzerland; Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, CH-4055, Basel, Switzerland; Department Biozentrum, Life Sciences Training Facility, University o
J Psychiatr Res ; 83: 260-268, 2016 12.
Article em En | MEDLINE | ID: mdl-27710795
ABSTRACT
DNA methylation represents an important link between structural genetic variation and complex phenotypes. The study of genome-wide CpG methylation and its relation to traits relevant to psychiatry has become increasingly important. Here, we analyzed quality metrics of 394,043 CpG sites in two samples of 568 and 319 mentally healthy young adults. For 25% of all CpGs we observed medium to large common epigenetic variation. These CpGs were overrepresented in open sea and shore regions, as well as in intergenic regions. They also showed a strong enrichment of significant hits in association analyses. Furthermore, a significant proportion of common DNA methylation is at least partially genetically driven and thus may be observed similarly across tissues. These findings could be of particular relevance for studies of complex neuropsychiatric traits, which often rely on proxy tissues.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Saúde Mental / Ilhas de CpG / Epigênese Genética Limite: Adult / Female / Humans / Male Idioma: En Revista: J Psychiatr Res Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Saúde Mental / Ilhas de CpG / Epigênese Genética Limite: Adult / Female / Humans / Male Idioma: En Revista: J Psychiatr Res Ano de publicação: 2016 Tipo de documento: Article