An UPLC-MS/MS method for the quantitation of alectinib in rat plasma.

Huang, Xiang-Xin; Li, Yun-Xuan; Li, Xiang-Yu; Hu, Xiao-Xia; Tang, Peng-Fei; Hu, Guo-Xin

Huang, Xiang-Xin; Li, Yun-Xuan; Li, Xiang-Yu; Hu, Xiao-Xia; Tang, Peng-Fei; Hu, Guo-Xin.

Afiliação

Huang XX; Department of Pharmacology, School of Pharmacy of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Li YX; Department of Pharmacology, School of Pharmacy of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Li XY; Department of Pharmacology, School of Pharmacy of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Hu XX; Department of Pharmacology, School of Pharmacy of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Tang PF; Department of Pharmacology, School of Pharmacy of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Hu GX; Department of Pharmacology, School of Pharmacy of Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: hgx@wmu.edu.cn.

J Pharm Biomed Anal ; 132: 227-231, 2017 Jan 05.

Article em En | MEDLINE | ID: mdl-27768922

Assuntos

Carbazóis/sangue; Cromatografia Líquida de Alta Pressão/métodos; Piperidinas/sangue; Espectrometria de Massas em Tandem/métodos; Animais; Calibragem; Limite de Detecção; Modelos Lineares; Masculino; Inibidores de Proteínas Quinases/sangue; Ratos; Ratos Sprague-Dawley; Reprodutibilidade dos Testes; Sensibilidade e Especificidade

Palavras-chave

Alectinib; Pharmacokinetics; Rat plasma; UHPLCMS/MS

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Carbazóis / Cromatografia Líquida de Alta Pressão / Espectrometria de Massas em Tandem Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: J Pharm Biomed Anal Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

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