Role of statins in delirium prevention in critical ill and cardiac surgery patients: A systematic review and meta-analysis.
J Crit Care
; 37: 189-196, 2017 02.
Article
em En
| MEDLINE
| ID: mdl-27776336
ABSTRACT
BACKGROUND:
The data evaluating the role of statins in delirium prevention in the intensive care unit are conflicting and limited.METHODS:
We performed a systematic review and meta-analysis of literature from 1975 to 2015. All English-language adult studies evaluating delirium incidence in statin and statin nonusers were included and studies without a control group were excluded. Mantel-Haenszel model was used to calculate pooled risk ratios (RRs) and 95% confidence intervals (CIs). Statistical significance was defined as CI not including unity and P value less than .05.RESULTS:
Of a total 57 identified studies, 6 were included. The studies showed high heterogeneity (I2 = 73%) for all and moderate for cardiac surgery studies (I2 = 55%). Of 289 773 patients, statins were used in 22 292 (7.7%). Cardiac surgery was performed in 4382 (1.5%) patients and 2321 (53.0%) used statins. Delirium was noted in 710 (3.2%) and 3478 (1.3%) of the patients in the statin and nonstatin groups, respectively, with no difference between groups in the total cohort (RR, 1.05 [95% CI, 0.85-1.29]; P = .56) or in cardiac surgery patients (RR, 1.03 [95% CI, 0.68-1.56]; P = .89).CONCLUSIONS:
In critically ill and cardiac surgery patients, this meta-analysis did not show a benefit with statin therapy in the prevention of delirium.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
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Inibidores de Hidroximetilglutaril-CoA Redutases
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Delírio
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Procedimentos Cirúrgicos Cardíacos
Tipo de estudo:
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
J Crit Care
Assunto da revista:
TERAPIA INTENSIVA
Ano de publicação:
2017
Tipo de documento:
Article